Joe Mixon has now rushed for 50 touchdowns in his career.
The Texans running back, who eclipsed the 100-yard mark for the day late in the third quarter, galloped in for a 3-yard touchdown in the fourth quarter on a toss to the left side.
It was his 20th carry of the day, and it pushed him to 119 yards on the afternoon, with 13:41 remaining in the contest.
Mixon's also caught 13 touchdowns.
The new Texans capped off a 13-play, 70-yard scoring drive that burned 6:59 off the game clock.
