Johnathan Joseph picked an excellent time to pick off a pass.

The Texans and Bills were knotted up at 13-apiece, with 1:30 left in regulation. The cornerback jumped in front of a Nathan Peterman 2nd-and-10 throw at the Buffalo 28-yard line, and galloped in untouched for the go-ahead score. It was his first interception of the season, and it delivered the Texans their third win. His defensive backfield mate and longtime friend Kareem Jackson picked off Peterman on the following possession, and the Texans were 3-3.

"It means a lot," Joseph said. "Last week we gave Kareem a hard time about not being able to seal it off. This week I had a chance to do it. It's a great feeling, to win the game for your team. But every guy on this team made plays that contributed to this win."

For Joseph, it was his 29th career interception, and his 15th as a Texan. Jackson relished seeing Joseph seal the win.

"It's huge for us as a defense," Jackson said. "Those are the type of plays that we want to make, week in and week out. It was a great call by Coach Rac (defensive coordinator Romeo Crennel). Put us in a great situation. We disguised it well. It was a huge play by Joe. 13-year vet. He's been making those plays for a long time. For me, I'm always happy to see him, especially get that pick and go to the crib with it."

Safety Tyrann Mathieu said Joseph knew there was an opportunity if the Texans saw the same sort of formation from the Bills.

"The play before that, J-Joe looked at me and said if they run that same concept, that he was going to jump it," Mathieu said. "And he jumped it. He walked in."

For the eighth time in his career, Joseph scored a defensive touchdown. It was his seventh interception return for a score. When Joseph caught it, he had a bit of time to ponder what was next.

"I kind of thought for a second to get there and just kind of hold the ball so we can run the clock out," Joseph said. "But then I was like 'A chance like that doesn't come by so often. I gotta score this.'"

Head coach Bill O'Brien was impressed with the play, and with the football smarts of the veteran defender.

"He just had an idea and he's been playing so long," O'Brien said. "One of the reasons why is because of how intelligent he is. He made a great play right there."

 It was the fourth pick-six as a Texan for Joseph, which is a franchise record.

Joseph and the Texans will face the Jaguars in Jacksonville next Sunday.