Can't-Miss Play: Mixon hits all the Madden buttons on incredible TD run

Houston Texans running back Joe Mixon hits all the Madden buttons on his incredible touchdown run against the Indianapolis Colts.

Houston Texans running back Joe Mixon's bruising run goes for 21 yards against the Indianapolis Colts.

Houston Texans kicker Ka'imi Fairbairn's 34-yard field goal boosts the Texans' lead 23-13 over the Indianapolis Colts.

Houston Texans wide receiver John Metchie snags a career long 28-yard reception following a quarterback C.J. Stroud roll-out against the Indianapolis Colts.

Houston Texans linebacker Jake Hansen corrals Indianapolis Colts quarterback Anthony Richardson for a sack.

Houston Texans kicker Ka'imi Fairbairn gives the Texans a 20-10 lead over the Indianapolis Colts following a 35-yard field goal.

Houston Texans quarterback C.J. Stroud strikes with a 49-yard toss to a wide open wide receiver Stefon Diggs against the Indianapolis Colts.

Houston Texans wide receiver Xavier Hutchinson makes an unreal diving grab for 19 yards against the Indianapolis Colts.

Houston Texans quarterback C.J. Stroud's touchdown pass to wide receiver Tank Dell gives the Texans a 16-10 lead over the Indianapolis Colts before halftime.

Houston Texans safety Jalen Pitre's interception nearly goes for a pick-six vs. Indianapolis Colts quarterback Anthony Richardson.

Houston Texans tight end Dalton Schultz catches a corner route pass for 17 yards against the Indianapolis Colts.

Houston Texans wide receiver Stefon Diggs' toe-tapping catch gets the Texans inside the Indianapolis Colts' 40-yard line.

The Houston Texans swarm Indianapolis Colts quarterback Anthony Richardson who can't escape the sack despite attempting to pass.

Houston Texans defensive end Will Anderson Jr. hunts down Indianapolis Colts quarterback Anthony Richardson from behind for an 8-yard sack.

Houston Texans quarterback C.J. Stroud hits a jump-pass to tight end Dalton Schultz for 16 yards to close out the first quarter in their matchup against the Indianapolis Colts.

Houston texans tight end Dalton Schultz slips upfield off slant pass for 16 yards against the Indianapolis Colts.

Houston Texans tight end Cade Stover slips tackle and stay alive for a 14-yard gain against the Indianapolis Colts.

Houston Texans kicker Ka'imi Fairbairn collects the first points of the game following a 35-yard field goal against the Indianapolis Colts.

Houston Texans quarterback C.J. Stroud dots wide receiver Stefon Diggs who was wide open over the middle for a 16-yard gain against the Indianapolis Colts.

The Houston Texans start off hot with running back Dameon Pierce's 45-yard opening kickoff return against the Indianapolis Colts.

After a last-second loss in Green Bay, the Houston Texans are gearing up to welcome the Indianapolis Colts to NRG Stadium on Sunday. How is Head Coach DeMeco Ryans prepping the team for a big AFC South showdown? Marc Vandermeer and John Harris asked him just that.

Plus get a game preview from Executive Vice President & General Manager Nick Caserio and tune in for Andre Johnson's chat with fellow Hall of Famer Cris Carter.

Texans Playbook is back!

Bobby Slowik spoke to the media from NRG Stadium.

Frank Ross spoke to the media from NRG Stadium.

Matt Burke spoke to the media from NRG Stadium.

C.J. Stroud spoke to the media from NRG Stadium.