The Texans will be without a pair of starters and several other key contributors on Sunday against the Bills.
Running back Joe Mixon won't play because of an ankle injury he suffered in Week 2, while right tackle Tytus Howard will be inactive due to a hamstring injury.
Backup running back Dameon Pierce is also out, so Cam Akers, Dare Ogunbowale and J.J. Taylor will likely split the carries on Sunday at NRG Stadium.
Because of an illness, starting linebacker and team captain Azeez Al-Shaair was listed Saturday as questionable for Sunday's game. But he's active.
Inactives
RB Joe Mixon
RT Tytus Howard
DE Derek Barnett
RB Dameon Pierce
WR Steven Sims, Jr.
LB Jake Hansen
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